Agriculture Business Week

It has been widely recognize that mannan-oligosaccharides(MOS) and B-glucans are beneficial to animal health. Mannan-oligosaccharides are known to be able to bind receptors of the intestinal cell wall, disease causing bacteria and mycotoxins elaborated by molds. It is also assumed that B-glucans have stimulating effect on the non-specific immune system.

The cell wall of brewer’s yeast (Saccharomyces cerevisiae) cells contains both MOS (25%) and B-(1, 3)-(1, 6)D-glucans (30%). One brewer’s yeast product is Biolex-MB 40. Processed by the Leiber GmbH of Germany, Biolex MB 40 consists of extracted, intact yeast cell walls.

CHEMICAL COMPOSITION
The proximate analysis of Biolex-MB 40 is as follows: crude protein, 25%; crude fat, 7%; crude fiber, 0.5%; crude ash, 4%; lysine, 2%; methionine, 0.55%; methionine + cystine, 1%; tryptophan, 0.20%; threonine, 1.6%; calcium, 0.15%; phosphorus, 0.45%; and sodium, 0.25%.

HIGH BONDING CAPACITY FOR PATHOGENS AND MYCOTOXINS
Owing to its surface structure and adsorption power, Biolex-MB 40 develops its gut-stabilizing effect and reduces infection strain.

Pathogens and toxins are bound to mannose molecules (fibrils) of the brewer’s yeast cell wall and either transported out of the gut or detoxified by the varied microbe population of the large intestine.

Biolex-MB 40 also occupies specific receptors in the mucous membrane of the intestine and supports the formation of a protective mucous barrier (biofilm). Pathogens are no longer capable of adhering and their infection-inducing toxin secretion has no effect. Moreover, the intestinal barrier is protected against access from mycotoxins such as zearalenone (ZEA), deoxynivalenol (DON), and ochratoxin (OTA).

Compared with other binding agents, this selective protection mechanism has the advantage that nutrients and active ingredients are not bound or deactivated.

ACTIVATES THE NON-SPECIFIC IMMUNE SYSTEM – PROTECTION AGAINST INFECTION
Roughly two-thirds of the immune system defense system is localized in the mucous membrane of the gut. Thus, it represents one of the most vital barriers against infective agents.

In the first place, Biolex-MB 40 leads to a strengthening of the mucous membrane barrier of the intestine, which directly supports the disposition of resistance to infection. Secondly, Biolex-MB 40 conveys the bound and inactivated infective agents on its surface to the phagocytes (macrophages, granulocytes and natural killer cells) of the non-specific immune system. These eliminate (“devour”) the intruders and trigger a multifaceted immune reaction, which leads to the increased formation of immunoglobulixis and to greater availability of macrophages, which are able to directly render pathogens harmless…

PREBIOTIC MOS
MOS cannot be degraded by the animals’ own enzymes. Biolex-MB 40 reaches the rear section of the gut, where it is available to the “positive naturally occurring flora” as a substrate for fermentation. As a result, the microbial conversion processes of bifidobacteria and lactic acid bacteria are stimulated in monogastric species, as are the cellulytic rumen microbes in ruminants.

Indirectly, the growth of pathogens diminishes because they are unable to exploit Biolex-MB 40 for energy purposes. In addition, the environment of the “positive naturally occurring bacteria” offers unfavorable conditions for the development of infective agents.

Biolex-MB 40, which is distributed locally by Broadchem Corporation, has a stabilizing effect on stomach and gut by improving the digestibility of the organic mass, and reducing the incidence of fermentation problems and scours, particularly in young animals.

Recommended Usage

Species              Dosage            Range of Effects
Sows                 0.5 kg/ton        – Protects against infection; reduces
Piglets                 1 kg/ton            colonization of gut with agents causing
scours (Salmonella, E. coli, Candida albicans, etc.)
- Fewer losses and longer useful life
- Binds and detoxifies mycotoxins such as
zearalenone, DON, and OTA.
- Better growth performance

Calves, rearing         1.0 kg/ton        – Stabilizes the digestive processes
Calves, fattening      1kg/ton           – Protects against infection and reduces losses
Cows                       1.0 kg/ton        – Increases the digestibility of the organic mass and
intensifies formation of short-chain fatty acids

Laying hens                             – Stabilizes the digestive processes
Broiler chickens                         through prebiotic oligosaccharides
Turkeys, geese                         – Reduces infectious strain in intensive poultry farming
- Improves rearing and fattening performance

Trout                                       – Increases resistance to infection in intensive farming
Salmon                                    – Reduces loss rates
Tilapia                                     – Prebiotic components for stabilizing the gut
Koi

Cats                                         – Optimizes the digestive processes when feeding concentrated rations
Dogs                                        – Increases the defences in young and adult animals alike
Horses                                     – Establishes healthy and stable intestinal flora

By Jaime Abella Sison